Addressing Toxicity Risk when Designing and Selecting Compounds in Early Drug Discovery

Summary

In this article, ‘Addressing toxicity risk when designing and selecting compounds in early drug discovery‘, we discuss the application of expert knowledge-based predictions of toxicity. We highlight how they can be used with multi-parameter optimisation, to guide the design and selection of high quality compounds with a reduced risk of toxicity, early in the drug discovery process.

Citation details

M. D. Segall, C. Barber, Drug Discovery Today, 2014, 19(5), pp. 688-693
DOI: 10.1016/j.drudis.2014.01.006 

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