Compound design and optimisation

Confidently decide which compounds to synthesise and advance with StarDropTM

StarDrop is an intuitive platform for molecular design, optimisation and data analysis. It brings together predictions and experimental data to help you balance activity with ADME and toxicity risks. Despite the uncertainties in all measured or predicted data, StarDrop gives you the evidence to defend your decisions and reach your goals faster.

Backed by rigorous peer-reviewed science

5

Granted and filed patents

StarDrop overview
Watch the StarDrop overview

Our platform

One connected platform, from design to decision

StarDrop platform

End-to-end drug discovery platform

Save time by connecting fragmented workflows

Flexible deployment & support

Lower adoption barriers, faster time to value

Intuitive design & analysis

Find insights faster with less training burden

Real-time collaboration

Make faster progress, together

Cutting-edge predictive science

Reduce costly synthesis by predicting earlier

Smarter compound selection

Focus resources on the compounds likely to succeed

Know when your data supports a decision

StarDrop helps you decide which compounds to make and which to advance, even when the data are uncertain:

  • Bring predictions and experimental data together in one design workflow
  • Prioritise your compounds with our Probabilistic Scoring approach to multi-parameter optimisation, accounting for the uncertainty behind every data point
  • Avoid missing good compounds because of uncertain measurements or predictions
  • Defend your decisions under expert review
  • Confidently prioritise across programmes and portfolios

Unlike black-box tools, StarDrop makes the uncertainty in your data visible, so you can see when you can confidently decide between compounds and when the data don’t support your decision. Teams choose what to make, test and advance with greater confidence and efficiency.

Learn more about Probabilistic Scoring

Accuracy versus uncertainty box plot

The benefits

Fewer wasted cycles, better decisions

Quickly target high-quality compounds

Avoid leaving valuable compounds behind

Make decisions you can defend

What used to involve manually wading through thousands of pages of patent applications now takes less than 10 minutes and just a few clicks.

10min

instead of days of manual searching

Uwe Heinelt
Uwe Heinelt Medicinal Chemist, Sanofi

From hit to candidate

How it works

Connect fragmented workflows across a single platform to bring together compound design, optimisation and data analysis.

Aminotetraline matched pairs neighbourhood

Easy SAR analysis

Instantly understand and explore the structure-activity relationships in your chemical series.

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SAR plot

Clear data visualisation

Generate interactive charts, graphs and chemical spaces to better comprehend your data.

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StarDrop oral CNS scoring profile

Multi-parameter optimisation

Find compounds with the best balance of activity, ADME and physicochemical properties.

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Compounds grouped by chemical similarity in Card View stacks, so property trends and patterns in chemical series can be identified

Intuitive Card View®

A unique approach to visualising the relationships within your compounds and chemical series.

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The Glowing Molecule, highlighting regions of your structure with a positive or negative impact on a particular property

Dynamic Glowing Molecule™

Explore structure-property relationships with instant visual feedback on your optimisation strategies.

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Cutting-edge predictive science

Predict earlier, synthesise the right compounds

A comprehensive range of rigorously validated in silico modelling and design capabilities, in one modular platform.

MPO strategy glowing molecule

Compound optimisation strategy

Identify the best property profile to select successful compounds for your objectives.

Surflex-Dock macrocycle 3D visualisation

3D molecular design

Understand compound activity in 3D and design better molecules.

Real-time collaboration

Make faster progress, together

  • Teams stay aligned, avoid duplicated effort, and make faster progress
  • Every idea is captured, ensuring that no opportunity is missed
  • Preserve institutional knowledge – learn from past decisions to drive future success
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StarDrop projects sharing a central molecule

Collaborative Projects

Shared spaces for compounds, data, and visualisations

Intuitive Workspaces

All team members can analyse and visualise project information in their own way

Shared Data Sets

A single source of truth for the compounds and data in your project

Centralised Idea Tracking

Capture all designs and decisions throughout the discovery process

Flexible deployment and support

Lower barriers to adoption, accelerate time to value

Flexible deployment

  • Enjoy identical functionality and user experience, with the option of desktop or cloud-based StarDrop
  • Choose from several hosted server options to suit your IT environment
  • Backed by Optibrium’s ISO27001-accredited Information Security Management System
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Customisation & integration

  • A modular platform that fits into real drug discovery environments
  • Easily integrate with your databases, predictive models and third-party tools
  • Embed StarDrop into existing workflows, scale usage over time, and realise value faster
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Training & support

  • Underpinned by industry-leading training and support
  • PhD-level scientists on call. Responses in hours, backed by tutorials, deep-dives and full documentation with no additional fees
  • Training centred around your own data, workflows and approaches
  • We help you make the most out of your StarDrop investment

Integrations

Python, Web Services

StarDrop connects with the databases, predictive models and third-party tools you already use, for example

Trusted by more than 200 global drug discovery teams

From top 10 pharma to small biotech and academia.

Sanofi Johnson & Johnson UCB BIAL Novalix

See it for yourself

Try StarDrop free for 30 days

Test it on your own projects, not just our case studies and stats. Scientists trust what they can test.

  • Unlock all features and capabilities
  • Apply StarDrop to your own data
  • Get personalised support and training
StarDrop screen preview