Alan Naylor led a stimulating discussion on drug discovery targeting inhibition of protein-protein interactions at our 2012 Drug Discovery Consultants’ Day. This raised many important questions including the potential need to consider compounds outside of ‘Lipinski-compliant’ space, while noting that some traditional small molecule inhibitors of PPIs, with good oral properties, have recently been discovered.

For details of the questions addressed, you can download a copy of Alan’s slides as a PDF.