25HT1A library with scoresID T*5HT1A Project Profile*5HT1A Project Profile*5HT1A Project Profile 2C9 pKi*2D6 affinity category(5HT1a affinity (pKi)BBB category0BBB log([brain]:[blood])HIA categoryP-gp categoryPPB90 categoryhERG pIC50logPlogS*5HT1A Project Profile*5HT1A Project Profile (5HT1a affinity (pKi)@??@??@#zlogSb__BIOFOCUS__logS_3f92bbaba650ea90765323358dc53767??????@!HIA categoryr__BIOFOCUS__HIA_category_54a507608dba628340d32f1dfa4a150a?333336!-+logPb__BIOFOCUS__logP_7f386de520a9b5ed36f3f316692b6bb11?ٙ?ٙ@ ??@ ?ٙ?ٙ\ @0BBB log([brain]:[blood])2__BIOFOCUS__BBB_cont_2012ə??Ŀə????? =p ? =p 33@? =BBB category4__BIOFOCUS_BBB_category_RF?ᙙ~R-+P-gp category8__BIOFOCUS__P$gp_category_RF?enoyeshERG pIC50n__BIOFOCUS__hERG_pIC50_8141cd003b19c56eae1efbf895eb98f7@??@?333333?333333@@"2C9 pKi,__BIOFOCUS__2C9_pKi_RF,@??@?ffffff?ffffff@@@4A@*2D6 affinity category__BIOFOCUS__2D6_affinity_category_3a5194f7bd1fe7cfddb3513664be5064?333334?333334low mediumhighvery highPPB90 categoryx__BIOFOCUS__PPB_90Thresh_RF_de67fc13b77ccb91aba1844be90d89ff?əJlowhigh??Structure<Rule/> Name5<Rule/> 0(5HT1a affinity (pKi)b<RulesList> <Rule> <Column>5HT1a affinity (pKi)</Column> <UserCreated>1</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>5</Units> <SDType>0</SDType> <SD>0.3</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>0</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> !Chemistry<RulesList> <Rule> <Column>Chemistry</Column> <UserCreated>1</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.166667" Name="2(arylcycloalkylamine) 1-indanol" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.166667" Name="arylpiperazine" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.166667" Name="arylpiperidine" Index="2"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.166667" Name="aminotetraline" Index="3"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.166667" Name="N-aryloxyethylindolealkylamines" Index="4"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.166667" Name="aporphine" Index="5"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList> logSb__BIOFOCUS__logS_3f92bbaba650ea90765323358dc53767 __BIOFOCUS__logS&Aqueous solubility Continuous model predicting aqueous solubility (log uM) based upon in vitro data b__BIOFOCUS__logS_3f92bbaba650ea90765323358dc53767@!><RulesList> <Rule> <Column>logS</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>2</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> logS @ pH7.4h__BIOFOCUS__logS7$4_d2030aacf943a9d0cdd809d8a80b0175&__BIOFOCUS__logS7$4(Solubility at pH 7.4Continuous model predicting apparent solubility at pH 7.4 for charged compounds (log uM)h__BIOFOCUS__logS7$4_d2030aacf943a9d0cdd809d8a80b0175-@!N<RulesList> <Rule> <Column>logS @ pH7.4</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>2</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> logPb__BIOFOCUS__logP_7f386de520a9b5ed36f3f316692b6bb1 __BIOFOCUS__logP(logP(octanol/water) tContinuous model predicting logP based upon in vitro data b__BIOFOCUS__logP_7f386de520a9b5ed36f3f316692b6bb11\ @><RulesList> <Rule> <Column>logP</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>7</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> logDh__BIOFOCUS__logD7$4_5a43f66b6964b1caea109e8162db5565&__BIOFOCUS__logD7$4logD at pH 7.4Continuous model predicting logD at pH 7.4 based on in vitro datah__BIOFOCUS__logD7$4_5a43f66b6964b1caea109e8162db5565Bff`@><RulesList> <Rule> <Column>logD</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>7</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> 2C9 pKi,__BIOFOCUS__2C9_pKi_RF&__BIOFOCUS__2C9_pKi4Cytochrome P450 CYP2C9 pKiContinuous model predicting 2C9 affinity (pKi) based upon in vitro data,__BIOFOCUS__2C9_pKi_RF,@@@4A@D<RulesList> <Rule> <Column>2C9 pKi</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>1</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> hERG pIC50n__BIOFOCUS__hERG_pIC50_8141cd003b19c56eae1efbf895eb98f7,__BIOFOCUS__hERG_pIC50hERG pIC50zHuman Ether-a-Go-Go related gene potassium channel inhibitionn__BIOFOCUS__hERG_pIC50_8141cd003b19c56eae1efbf895eb98f7@@"J<RulesList> <Rule> <Column>hERG pIC50</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>5</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> 0BBB log([brain]:[blood])2__BIOFOCUS__BBB_cont_2012(__BIOFOCUS__BBB_cont>Blood-brain barrier penetrationContinuous model predicting log([brain]:[blood]) based on in vivo data.2__BIOFOCUS__BBB_cont_201233@? =f<RulesList> <Rule> <Column>BBB log([brain]:[blood])</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>7</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> -BBB category4__BIOFOCUS_BBB_category_RF0__BIOFOCUS__BBB_category>Blood-brain barrier penetration<Two class category model based upon classified log([brain]:[blood]) in vivo data: class ' + ' indicates a ratio >= -0.5 class ' - ' indicates a ratio < -0.54__BIOFOCUS_BBB_category_RF~R<RulesList> <Rule> <Column>BBB category</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.5" Name="-" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.5" Name="+" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList> VHIA categoryr__BIOFOCUS__HIA_category_54a507608dba628340d32f1dfa4a150a0__BIOFOCUS__HIA_category8Human intestinal absorption Two class category model based upon human in vivo data: class ' + ' indicates absorption >= 30% class ' - ' indicates absorption < 30% r__BIOFOCUS__HIA_category_54a507608dba628340d32f1dfa4a150a!<RulesList> <Rule> <Column>HIA category</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.5" Name="-" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.5" Name="+" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList>  P-gp category8__BIOFOCUS__P$gp_category_RF2__BIOFOCUS__P-gp_category0P-glycoprotein substrateTwo class category model based upon in vitro data: class 'yes' indicates a substrate class 'no' indicates a non-substrate8__BIOFOCUS__P$gp_category_RFe<RulesList> <Rule> <Column>P-gp category</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.5" Name="no" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.5" Name="yes" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList> *2D6 affinity category__BIOFOCUS__2D6_affinity_category_3a5194f7bd1fe7cfddb3513664be5064B__BIOFOCUS__2D6_affinity_category@Cytochrome P450 CYP2D6 affinity Four class category model based upon in vitro data: class 'low' indicates a pKi < 5 class 'medium' indicates a pKi in the range 5 - 6 class 'high' indicates a pKi in the range 6 - 7 class 'very high' indicates a pKi > 7 __BIOFOCUS__2D6_affinity_category_3a5194f7bd1fe7cfddb3513664be5064<RulesList> <Rule> <Column>2D6 affinity category</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.25" Name="low" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.25" Name="medium" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.25" Name="high" Index="2"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.25" Name="very high" Index="3"> <Probabilities> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList> PPB90 categoryx__BIOFOCUS__PPB_90Thresh_RF_de67fc13b77ccb91aba1844be90d89ff6__BIOFOCUS__PPB_90Thresh_RFNPlasma protein binding (90% threshold) tTwo class category model based upon in vitro data: class 'low' indicates < 90% of compound bound to plasma protein class 'high' indicates >= 90% of compound bound to plasma protein x__BIOFOCUS__PPB_90Thresh_RF_de67fc13b77ccb91aba1844be90d89ffJ<RulesList> <Rule> <Column>PPB90 category</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Unknown="0.5" Name="low" Index="0"> <Probabilities> <Probability Value="1"/> <Probability Value="0"/> </Probabilities> </Category> <Category Unknown="0.5" Name="high" Index="1"> <Probabilities> <Probability Value="0"/> <Probability Value="1"/> </Probabilities> </Category> </Categories> </Rule> </RulesList> MW^__BIOFOCUS__MW_74e6485ded93311b57808ad30b2468b3__BIOFOCUS__MW Molecular Weight.Relative molecular mass^__BIOFOCUS__MW_74e6485ded93311b57808ad30b2468b3m @:<RulesList> <Rule> <Column>MW</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> HBD`__BIOFOCUS__HBD_75d53ae5cf8645d4a8e47d2bf47e8f0c__BIOFOCUS__HBD2Hydrogen bond donor countDCount of NH, NH2, nH and OH groups`__BIOFOCUS__HBD_75d53ae5cf8645d4a8e47d2bf47e8f0c]]@$<<RulesList> <Rule> <Column>HBD</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> HBA`__BIOFOCUS__hba_03322d99413954aca66077b9261c6847__BIOFOCUS__hba8Hydrogen bond acceptor count Count of O and N`__BIOFOCUS__hba_03322d99413954aca66077b9261c6847{ @0<<RulesList> <Rule> <Column>HBA</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> TPSAd__BIOFOCUS__PSANO_961b77a2a38cfc247df40dd8558a90cc"__BIOFOCUS__PSANO<Topological Polar Surface AreabTopological Polar Surface Area based upon N and Od__BIOFOCUS__PSANO_961b77a2a38cfc247df40dd8558a90cc'@o@><RulesList> <Rule> <Column>TPSA</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> Flexibilityb__BIOFOCUS__FLEX_40efead18392c900847b50bfaa3160cb __BIOFOCUS__FLEX"Flexibility indexLProportion of bonds that are rotatableb__BIOFOCUS__FLEX_40efead18392c900847b50bfaa3160cbSI@4L<RulesList> <Rule> <Column>Flexibility</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> Rotatable Bondsj__BIOFOCUS__ROTBONDS_c290a49b5bb4e576a4ab69d9349996ff(__BIOFOCUS__ROTBONDS2Number of rotatable bondsDNumber of bonds that are rotatablej__BIOFOCUS__ROTBONDS_c290a49b5bb4e576a4ab69d9349996ffQe@4T<RulesList> <Rule> <Column>Rotatable Bonds</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>0</Units> <SDType>0</SDType> <SD>0</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>1</KeepOriginals> <UseValue>1</UseValue> </Rule> </RulesList> F? ?|`?  2C9 pKi?`*2D6 affinity category? (5HT1a affinity (pKi)?_BBB category?x0BBB log([brain]:[blood])?HIA category?k`P-gp category?`PPB90 category?@hERG pIC50?.@logP?HlogS? *COc1cccc2CC3NCCC3Cc12*COc1cccc2CC3NCCC3Cc12⾕Mvδ߁AF¡Zs=@phVxku٬&k^J7Ǯl(ޖ_v!,H^}6ǭ9?"}@ҙ'cb-յpRe/'[ZJQiӽ'8a S1-46S1-467.640.3@\ ?33@Raminotetraline?] ?ǁn?-Fq J,8ɜj u%?3?~ ХL@$U?]@_?.^`?C@v̥w`[ f^`@@Q?M?#t ?[?v`G?SZ?ߜ]?W?MM`?á`?S@?@?#?ϤI?`??& ?& ?& r (l׀?ˢ??ح]?Ъ?b?s ?`?\?>?{X?7B@?ۆ}@?a ?t?Z?`кT $`Q?s@?m_`?]? ?@.@?q?` C`(ʔoXsҀp&w@ @?=]?f?Ыg?ײX@?Ыa? ??? ?z? ?a?O? <  @?7@@H ? ]?f?9Ɗ;YW@S ܀ƭ$#n"@ѳ 3 yI=@o?bl?z?R?33??R?z??zzRGz?z??l?e ?ɠl?z? =?z?z@?G?z@?Q`?@?ə?(? =??G?z?z?z?У?\ ?G|?`؀?͉ؠ?;?ñ; ?; l =33@?z?z`??? =?R?z?z? =z?z?z`?=p? =]?/`?/`?[`?/`?/`?/`?/`?/`?/`?/`?/`?/`?/`?/`?/`?`?[`?/`@n]??]?UU`?UU`?UU`@]?"?"?"?"??ה ?@G*=]?????]????@F?ڽ?r ?V` 2C9 pKi?L*2D6 affinity category?ܠ(5HT1a affinity (pKi)? BBB category?@0BBB log([brain]:[blood])?HIA category?k`P-gp category?zPPB90 category?ȴ@hERG pIC50?~{`logP?logS?}8CN1CCC2C1CCc3cccc(C(=O)N)c238CN1CCC2C1CCc3cccc(C(=O)N)c23OבKĥ3q/`Rlߏ#SvJ?Yo1md*ޖn1C_] ƅk&>pRd/'[ZJQiӽ'8a S1-45S1-457.390.3@\ ?33@Raminotetraline?Y?C??ؚ#?ݳ`͙`?4?~}@?Y?˴ ? ??·|?+?ʸ0?ʙ?!?T?xl?;?p?˼??Έ?`? @^?=Y?+J?y4`?`? ?Xk? ?Pl ????Y?ҧ/`?1@@[w?ޭYW9@mJ &@OZ ^yy`ŀ}5 AY`ۄ<@?bh?z?z??z?z?zzzzzə녀?z?p?h?e ?ɠh? =?R? ?θR?z`? =?ə?ə?R?z?(? =????(?׮x?`؀?͉ؠ?;?ñ; ?; hzRR?z? z??z@??R?z?z?(?z?zz? =`? ?QY? ?%q@? ? ? ? ? ? ? ? ? ? ? ? ?@?%q@? @lzY??Y?UU`?UU`?UU`@Y?"?"?"?"??ה ?@G*=Y???Y???F??۠?ۭ@ 2C9 pKi?*2D6 affinity category?ܠ(5HT1a affinity (pKi)?BBB category?뙙0BBB log([brain]:[blood])?XHIA category?k`P-gp category?pPPB90 category?ff`hERG pIC50?֠logP?` logS?>NC(=O)c1cccc2CCC3C(CCN3CC=C)c12>NC(=O)c1cccc2CCC3C(CCN3CC=C)c12OבKĥ3q/Rlߏ#SvN?Yo1mf:ޞqC_]捨ƅk&>prݏ5e?'[ZQiӽ/З8a S1-47S1-478.820.3@!?33@Raminotetraline?a?қS?@)    ĕ Y-7?^?ʡ?G͠@?)`a?̺?|??@# `ǝFNjľ :>P n`?zD@$@`І?~{?ߜakOxݡϮ?<[ ?<[ ?<[ ?˲@?S?кA ?Նy?s|??/??"`?ɋ?o`?`?حaK@Fj?ڵ$@?m`?U ? ??t ? `?Rf?Ö? ?û-R`?Ow@?DF?J ?T ??agYH1IPh"pP?K ??cvx@ @?=a,ɀu#j?#`????zM: ???~?ס?з)?[??!`?t ?= @ ?oafׂaF ` Ȁ&reHIA category?k`P-gp category?=pPPB90 category?+hERG pIC50?gglogP?logS?. >NC(=O)c1cccc2CCC3C(CCN3CC#C)c12>NC(=O)c1cccc2CCC3C(CCN3CC#C)c12OKĥ3s/`Rl߯#[vJ?Yo1ml:ޖn5C_] ƅ k&>pR/u/'Z?JQiӽ'ȗ8 S1-56S1-567.320.3@G ?33@Raminotetraline?a?B?j8:S   ʏpuIJe@?*?$ ?2S9`@}?a?v?7?? ?Y^[`&@Ś ^h;`{ ?#`~:`?s?ߜay????J`??y?Dz ?Ǜ?@?Ƀ @??nt??w ?*?حahM ~֌?@?%4??מ8 ?ڴ????s?@?~% 8?D?S@??[b??a>?0 XTŔDl?L`? ?`ʼnpq@ ?=aǀ^ #?`?U`??yx@c ?`??צ`?% ?оP?1x?C`???w`@@?8RahOΠƹ(’@CYe#R`!~`U:Ƞ*? Lo&?mf,֫?bp =pzRz???R???z?z?G ?\)p?e ?ɠp? =?녀?z?G??z? =?G?@? ? =?θR? ?z?(z?G ?z@? =؀?`?͉ؠ?;?ñ; ?; pQ?R?R?R?z?z?(?z?zQ?(z @?z?R? =??pa?3?1? ?1?1?1?1?1?1?1?1?1?1?1?3?1?1?1?1@oa??a?UU`?UU`?UU`@a???ה ?"?"?"?"@G*=a?A ?A ?A ?A ?A ?I$a?UU`?UU`?UU`?UU`?UU`@F?0?>?ظ` 2C9 pKi?텀*2D6 affinity category? 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