by mchenery | Apr 12, 2022 | Drug Discovery Applications, Multi-Parameter Optimisation, Publications and presentations
This article is a collaboration with Intellegens, the University of Cambridge and AstraZeneca. It provides a proof-of-concept study in which Cerella™ is used to predict rat in vivo pharmacokinetic (PK) parameters and concentration–time PK profiles. Authors Olga...
by Marina Chenery | Oct 19, 2016 | Multi-Parameter Optimisation, Publications and presentations
Summary There are a number of criteria to balance when looking to select a successful drug candidate. But how can we consider the impact of the compound selection criteria we choose on the decisions we make? This peer-reviewed article, published in the Journal of...
by Marina Chenery | Mar 27, 2015 | Multi-Parameter Optimisation, Publications and presentations
Practical Application of Multi-Parameter Optimization to Guide Successful Drug Discovery Dr Matt Segall, Optibrium, gave this presentation at the “Guiding Optimal Compound Design and Development Symposium” held in Cambridge, MA, USA on 19 March 2015....
by Marina Chenery | Apr 7, 2014 | Multi-Parameter Optimisation, Publications and presentations
Summary This review article discusses recent developments in the methods and opinions around multi-parameter optimisation, focusing on applications to de novo drug design and illustrated with published examples. Read now to discover more on the latest advances in...
by Marina Chenery | Apr 2, 2014 | Multi-Parameter Optimisation, Publications and presentations
Advances in Multi-Parameter Optimisation: Targeting the ‘best’ profile for your project’s objectives Ed Champness gave this presentation at the ACS Spring 2014 National Meeting & Exposition held in Dallas, USA on 16th March 2014. Abstract Multi-parameter...
by Marina Chenery | Mar 24, 2014 | Multi-Parameter Optimisation, Publications and presentations
Finding and Applying Multi-Parameter Rules to Guide Successful Drug Discovery Matt Segall gave this presentation at the International Symposium on Compound Design Technologies held in Tokyo and Osaka, Japan on 19 and 20 March 2014. AbstractA high quality drug must...