by Marina Chenery | Oct 23, 2012 | General, Multi-Parameter Optimisation, Publications and presentations
Summary There are many different definitions of ‘drug-like’, with rules proposed based on property trends seen in successful drugs. In the paper we review the strengths and weaknesses of these different definitions of ‘drug-like’ properties and...
by Marina Chenery | Oct 16, 2012 | Downloads, Models
P-gp Transporter Models P-glycoprotein (P-gp) is an ATP driven efflux pump encoded by the MDR1 gene, capable of transporting a wide spectrum of chemical structures as well as different classes of drugs. Active transport by P-gp can represent a serious hurdle for...
by Marina Chenery | Oct 14, 2012 | Downloads, Models
Caco-2 Model Permeability across monolayers of the Caco-2 line of human epithelial colorectal adenocarcinoma cells is a common in vitro model used to assess potential of compounds to be absorbed across the human intestine. The apparent permeability (Papp) from the...