StarDrop's P450 metabolism models identify the regions of a candidate molecule most vulnerable to metabolism by the three major cytochrome P450 enzymes. These enzymes account for around 95% of human Phase 1 metabolism.
Using StarDrop's P450 metabolism models molecules can be redesigned to overcome possible metabolism problems or drug-drug interactions. Combining these models with other factors such as the molecule's affinity or lipophilicity can demonstrate the risk of high metabolic turnover.
If you would like to know more about how these models work, take a look at the FAQs. The P450 models are available as an optional module for StarDrop. To find out more about StarDrop and the P450 module or to arrange an online demonstration please contact us.
