The following case studies demonstrate examples of what StarDrop is capable of. If you'd like to know more or arrange an on-site demonstration, contact us for more details.
Focusing resources in hit-to-lead
Having screened over 3,000 compounds from a virtual library of more than 13,000, our client was faced with multiple hits across 13 different chemistries. The team needed to decide where best to focus their efforts at the synthesis stage in order to make the most of their resources - which StarDrop enabled them to do. Read more...
In silico guided hit-to-candidate
An ambitious client was planning to identify a novel drug candidate for a cardiac target and progress it to Phase I clinical trials within two and a half years. StarDrop was used to analyse initial hits against the target so the chemistry program could focus on a limited number of compounds with a high chance of success, leading to a clinical candidate. Read more...
Rapid focus in lead optimisation
Our client was working to identify a therapy for a CNS target, but hadn't been able to find one with the right combination of oral bioavailability and CNS penetration. Using their project data, we were able to demonstrate how StarDrop could help them identify compounds at an earlier stage, saving time and money. Read more...
Balancing properties in lead optimisation
Initial selection of possible candidates from a set of 150 compounds had been based on potency and selectivity - but had ignored potential solubility and metabolic stability problems. With disappointing bioavailability from in vivo studies, our client asked us to use their data to provide a more balanced set of compounds for progression from their candidates. Read more...
